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Check Intently (one)pentobarbital will lessen the level or effect of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to your decrease in fentanyl plasma concentrations, lack of efficacy or, probably, advancement of a with